Indie software from homebrew
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SigmaOS
Web browser
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Signal
Instant messaging application focusing on security
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signal-cli
CLI and dbus interface for WhisperSystems/libsignal-service-java
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signalwire-client-c
SignalWire C Client SDK
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signify-osx
Cryptographically sign and verify files
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signmykey
Automated SSH Certificate Authority
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sigstore
Codesigning tool for Python packages
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sigsum-go
Key transparency toolkit
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sile
Modern typesetting system inspired by TeX
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Silhouette Studio
Design software for Silhouette cutting machines
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silicon
Create beautiful image of your source code
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Silicon
Identify Intel-only apps
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Silicon Info
View the architecture of the running application
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Silicon Labs VCP Driver
CP210x USB to UART Bridge VCP Driver
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silk
Collection of traffic analysis tools
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SILKYPIX Developer Studio 8 SE
RAW image development software used with Panasonic products
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Silo
3D polygonal modeller and UV mapper
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Sim Daltonism
Colour blindness simulator for videos and images
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Sim Genie
Easier access to Xcode Simulator functionality
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simde
Implementations of SIMD intrinsics for systems which don't natively support them
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simdjson
SIMD-accelerated C++ JSON parser
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simdutf
Unicode conversion routines, fast
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simg2img
Tool to convert Android sparse images to raw images and back
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simgrid
Studies behavior of large-scale distributed systems
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SimPholders
Access utility for iPhone Simulator apps
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simple-amqp-client
C++ interface to rabbitmq-c
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Simple Comic
Comic viewer/reader
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simple-mtpfs
Simple MTP fuse filesystem driver
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simple-obfs
Simple obfusacting plugin of shadowsocks-libev
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simple-scan
GNOME document scanning application
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simple-tiles
Image generation library for spatial data
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Simple Web Server
Create local web servers
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Simple Clock Screensaver
Simple analogue clock screensaver written entirely in Swift
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SimpleDEMViewer
Digital Elevation Model viewer
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SimpleMind
Cross-platform mind mapping tool
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Simplenote
React client for Simplenote
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SimpleTex
Formula snipping and recognition app
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Simply Fortran
Fortran development environment
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SimplySign Desktop
Emulates a physical crypto card/reader for proCertum SmartSign
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SimSim
Tool to explore iOS application folders in Terminal or Finder
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simutrans
Transport simulator
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since
Stateful tail: show changes to files since last check
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Singlebox
Multi-account web browser
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SingleCrystal
Crystal diffraction software
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singular
Computer algebra system for polynomial computations
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Singularity Viewer
Client for Second Life and OpenSim
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Sioyek
PDF viewer designed for reading research papers and technical books
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sip
Tool to create Python bindings for C and C++ libraries
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Sip
Collect, organise & share colours
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sipcalc
Advanced console-based IP subnet calculator
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sipgate
Softphone for making telephone calls over the internet
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Sipgate Softphone
Make telephone calls on the computer
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sipp
Traffic generator for the SIP protocol
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sipsak
SIP Swiss army knife
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siril
Astronomical image processing tool
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SiriMote
Control your computer with your Apple TV Siri Remote
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sisc-scheme
Extensive Java based Scheme interpreter
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sispmctl
Control Gembird SIS-PM programmable power outlet strips
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Sitala
Drum sampler plugin and standalone app
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sitefetch
Fetch an entire site and save it as a text file